The San Francisco 49ers' Week 15 game with the Los Angeles Rams is a must-win, one for which they need all hands on deck. But it's looking increasingly likely they will once again be without two of their most important players.

As the 49ers prepare for their huge Week 14 matchup with the Rams, they will be without Trent Williams for another week in a must-win game.

San Francisco 49ers defensive end Nick Bosa and tackle Trent Williams have not practiced this week after missing their second consecutive game, casting