Nike co-founder Phil Knight and his wife Penny Knight have pledged to donate $2 billion to Oregon Health & Science University’s Knight Cancer Institute, the school announced Thursday, describing it as the largest single gift to a U.

Oregon Health & Science University said the couple’s donation would be the largest single gift to a higher-learning institution in the United States.

Knight is one of America’s most generous philanthropists, according to Forbes data, donating billions of dollars to educational institutions throughout his life.