San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second ...

Brock Purdy and the 49ers (6-7) raced to a 24-0 halftime lead and cruised to a 38-13 home win Sunday over the Chicago Bears ...

The Buffalo Bills were impressive in their week 13 destruction of a desperate and depleted San Francisco 49ers team, blowing ...

Sean McDermott and Josh Allen put that on full display during the final whistle. The head coach and quarterback for the Bills ...

After the Buffalo Bills' 35-10 beatdown of the San Francisco 49ers in Week 13, the team is now 16-3 since Joe Brady was ...

Von Miller and Los Angeles draft picks Taylor Rapp and David Edwards should be in the Bills’ lineup when Buffalo visits SoFi ...

Josh Allen and the Buffalo Bills are on a roll and up next is a Rams team that can be dangerous. Here are some Bills Week 14 ...

The AFC East champion Bills head to Los Angeles to play the Rams Sunday. Here's the broadcast and betting information.

Mia DeCamilla, an 8-year-old cancer survivor, said she was shoved by a Buffalo Bills fan while attending the team's game against the San Francisco 49ers on Sunday, Dec. 1 at Highmark Stadium.

Whether it’s introducing “Dad Joke Fridays” or making snow angels on the field with quarterback Josh Allen to celebrate the ...

The Buffalo Bills (10-2) head into Week 14 fresh off of a 35-10 home win over the San Francisco 49ers. Coming into the year, ...

The native Texan seemingly prefers to travel on horseback, but he has shown adaptability to different weather conditions. Cutting through the near two feet of snow that recently blanketed the ...