Christian McCaffrey's injury against the Bills could be due to the heavy workload he received since returning to the 49ers.

The San Francisco 49ers are moving forward without star running back Christian McCaffrey or backup Jordan Mason for the ...

There are bad bye weeks, and then there are season-ruining bye weeks. This could be the latter for many teams needing a ...

Former Wisconsin Badgers running back Isaac Guerendo is in line to serve as the San Francisco 49ers starting running back for ...

Rookie fourth-round pick Isaac Guerendo seemed to be an afterthought in the San Francisco 49ers backfield with Christian ...

The 2024 season has been a renaissance for running backs. After years of toiling away on middling teams, Philadelphia Eagles ...

The San Francisco 49ers’ 35-10 Week 13 loss to the Buffalo Bills was costly in more ways than one. Not only did it make San ...

The San Francisco 49ers' brutal battle against the injury bug continues to get worse, as they have lost their two main running backs — Christian ...

The San Francisco 49ers shored up their suddenly thin running back corps on Tuesday by claiming Israel Abanikanda off waivers from the New York Jets.

The 49ers signed two running backs to their practice squad after Christian McCaffrey and Jordan Mason were placed on injured ...

Defending the run has been one of the Green Bay Packers’ weaknesses over the last several years. Not so much lately, though.

NFL season appears to be over for Christian McCaffrey, which is why the San Francisco 49ers have added two new running backs ...