Among these sensors, we further focused on the spatiotemporal dynamics of Rab10 and Rab4 activity during sLTP. We found that postsynaptic stimulation leads to the persistent inactivation of Rab10 and ...

OSM-3, revealing that the kinase, NEKL-3, phosphorylates a serine/threonine patch at the hinge region of the motor to mediate autoinhibition until it reaches the ciliary middle segment. The findings ...

However, technical and study bias affect the experimental procedures for detecting PPIs. For instance, cancer-associated proteins have received disproportional attention. Moreover, bait proteins in ...

Endometriosis is a debilitating disease affecting 190 million women worldwide and the greatest single contributor to infertility. The most broadly accepted etiology is that uterine endometrial cells ...

To best serve the needs of researchers, eLife will provide a partial feed of research to be indexed in the Web of Science Core Collection. eLife will also move from the Scopus Journals Collection to ...

Toxoplasma gondii parasites can use secreted factors to compensate for genetic defects in neighbouring parasites, highlighting a limitation of pooled CRISPR screens.

Combining intermittent fasting with localised Wnt3a treatments can rejuvenate bone repair in older mice, offering hope for reversing age-related tissue decline.

By exploring the conservation and functional diversity of RIPK3 and related RHIM-containing proteins across vertebrates, this important work sheds light on the evolutionary dynamics of these key ...

This useful study highlights the largely redundant role of the decapping activators Edc3 and Scd6 in orchestrating post-transcriptional programs to modulate metabolic responses to nutrients in yeast.

This manuscript applies a theoretical analysis to two published datasets on yeast and bacterial evolution to compare different ways of quantifying fitness. It makes an important advance by clarifying ...

A mathematical model can predict the path walkers take through a rugged landscape, including the tendency of people to avoid paths that are too steep, even if it means going farther.

This study makes a valuable advance in our understanding of defensive symbionts in insects. It uses a meta-analysis to quantify the magnitude of change in host fitness components when symbionts are ...