Gut

Impact of initial severity and progression pattern of new-onset diabetes on pancreatic cancer risk: a 15-year longitudinal nationwide cohort study

Background New-onset diabetes (NOD) increases the risk of pancreatic cancer. Previous studies have mainly focused on the ...
Gut

Ustekinumab for fistulising perianal Crohn’s disease: a randomised placebo-controlled trial from the GETAID

Background Fistulising perianal Crohn’s disease (CD) remains a debilitating condition, with few randomised controlled trials ...
gut.bmj

Cancer risk in autoimmune gastritis: perspectives from a Chinese cohort

We read with great interest the study by Lenti et al published in Gut , providing the first large-scale assessment of clinical features and gastric neoplastic risk in autoimmune gastritis (AIG).1 ...
gut.bmj

DR1-DR2 enrichment in HBeAg-negative chronic hepatitis B: integration hotspot or survivor signature?

We read with great interest the recent study by Lau et al, who reported distinct intrahepatic hepatitis B virus (HBV) integration patterns according to HBeAg status and observed marked enrichment of ...
gut.bmj

Efficacy of gut-brain neuromodulators and brain-gut behaviour therapies for irritable bowel syndrome: systematic review and network meta-analysis

Background Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction, with some recommended treatments targeting brain-gut axis dysfunction. Objective To compare relative efficacy of ...
gut.bmj

From preclinical phase of Crohn’s disease to postoperative recurrence: shared mechanisms and potential interventions

Crohn’s disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract with high risk of surgery. Despite advances in medical treatment, of those patients who undergo ileocolonic ...
gut.bmj

Atypical diarrhea in an immunocompetent infant

A 2-month-old male infant was admitted with a 2-day history of cough and fever. Respiratory pathogen testing on admission confirmed influenza A (H1N1) virus infection. The patient was started on oral ...
gut.bmj

Urgent versus early ERCP in mild-to-moderate acute cholangitis: a randomised controlled trial

Background The optimal timing of endoscopic retrograde cholangiopancreatography (ERCP) in patients with mild-to-moderate acute cholangitis remains uncertain. Objective To compare the clinical outcomes ...
gut.bmj

Endosomal signalling of protease-activated receptor-2 amplifies histamine-induced pain of irritable bowel syndrome

Background Proteases and histamine, co-secreted by mast cells and bacteria, sensitise colonic nociceptors and contribute to irritable bowel syndrome (IBS) pain. Objective To determine whether ...
gut.bmj

MAIT cell enrichment in Lynch syndrome is associated with immune surveillance and colorectal cancer risk

Background Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC) and results from pathogenic germline variants affecting mismatch repair. The tissue microenvironment that ...
gut.bmj

Metabolic mechanisms of duodeno–ileal diversion: early bile acid and incretin signalling predict glycaemic outcomes

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be ...
gut.bmj

Seeing the unseen: AI radiomics unmasking occult pancreatic cancer?

Would it be not attractive to have a scalable, imaging-based method at hand to predict pancreatic cancer before the patient becomes symptomatic and before a lesion becomes visible to the human eye—by ...