The Chicago White Sox (14-30) visit the Chicago Cubs (25-19) to open a 3-game Crosstown Classic series Friday. First pitch from Wrigley Field is at 2:20 p.m. ET (MLB Network). Let's analyze BetMGM Sportsbook's MLB odds around the White Sox vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Cubs players Chris Flexen, Nicky Lopez and Brad Keller are looking forward to experiencing the other side of the City Series rivalry with the White Sox.

The White Sox were stymied in their efforts to win their third in a row yesterday as they were smacked by the Reds, 7-1. The Sox managed just four hits off Nick Martinez and a couple of Reds’ relievers. Miguel Vargas had two of the four hits for Chicago.

The Rule 5 Draft pick added to the roster just before Opening Day, Vasil notched his first career save as he gains confidence at the back of the pen.

Lenyn Sosa and Michael A. Taylor homered as Chicago improved to 14-29 with its season-high third consecutive win.