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Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
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MedVision Academy on Instagram: "Bleomycin (Blyomycine) 💉🧬 Drug Class Antitumor antibiotic 🦠 Chemotherapy agent 💊 Mechanism of Action ⚙️ Causes DNA strand breaks by generating free radicals 💥 Inhibits DNA synthesis → cell death Cell-cycle specific: Acts mainly in G₂ phase Indications / Uses 🎯 Hodgkin lymphoma Testicular cancer Squamous cell carcinoma (head & neck, cervix, skin) Part of ABVD regimen (Adriamycin, Bleomycin, Vinblastine, Dacarbazine) Major Adverse Effects ⚠️ Pulmonary toxicit
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