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A new paper found the estradiol level tied to protecting your heart and bones, and the guidelines haven't caught up. Piette and Simon (Gynecological Endocrinology, 2026) lined up serum estradiol from transdermal trials against KEEPS and ELITE. The protective range landed near 60 pg/mL. The twist: the most popular patch dose already delivers about 57. Women and their prescribers arrived there on their own. The honest catch: hormone therapy is guideline-approved for bone (osteoporosis) prevention,
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Causes of On-and-Off Pelvic Pain Intermittent pelvic pain can come from several systems: Gynecologic causes * Ovulation pain (mittelschmerz) * Menstrual cramps * Ovarian cyst * Endometriosis / endometrioma * Adenomyosis * Myoma (uterine fibroids) * Pelvic inflammatory disease (PID) * Endometrial or cervical polyps * Adhesions, especially after pelvic surgery or infection Pregnancy-related * Early pregnancy-related discomfort * Ectopic pregnancy — important to rule out when pregnancy is possible
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