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Opioid agonists produce analgesia by binding to G protein-coupled receptors (GPCRs) in the brain and spinal cord regions involved in the transmission and modulation of pain Opioid drugs mimic endogenous compounds: endorphins, enkephalins, and dynorphins that bind to opioid receptors. Four opioid receptor types: mu (μ), kappa (κ), delta (δ ...
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As a neurosurgeon, I see how some commonly used medications can quietly affect brain function and long-term neurological health. Here are five to watch out for: 🧠 1️⃣ Benzodiazepines (e.g., Alprazolam, Lorazepam, Diazepam): Commonly prescribed for anxiety and sleep, long-term use has been linked to memory impairment, slowed processing speed, increased fall risk, and dependency. Chronic exposure is associated with cognitive decline, especially in older adults. 🧠 2️⃣ Anticholinergic Drugs (e.g.,
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