Is Pregabalin addictive? Lyrica is not “as bad” as the media hype suggests, but caution is warranted. It is not more addictive than opioids — in fact, opioids carry a far higher risk. Problems usually arise from misuse, very high doses, or mixing with other drugs. For the right patient (e.g., neuropathic pain that hasn’t responded to other treatments), Lyrica can be very effective and improve quality of life. | ECT4Health- Nurse/Paramedic Education